Salute e Benessere
Vivoryon Therapeutics N.V. Shares Highlights from Virtual Kidney Disease KOL Event
– Vivoryon Therapeutics N.V. (Euronext Amsterdam: VVY; NL00150002Q7) ( ), a clinical stage company focused on the discovery and development of small molecule medicines to modulate the activity and stability of pathologically altered proteins, today announced key takeaways from its virtual Kidney Disease Key Opinion Leader (KOL) Event held September 30, 2024. The event focused on the standard of care and existing medical need, market development and dynamics in kidney disorders, as well as on key statistical considerations in kidney disease drug development, with special emphasis on diabetic kidney disease (DKD).
The event, which was hosted by Frank Weber, MD, CEO of Vivoryon, featured presentations from Tobias B. Huber, MD, Chair of the Center of Internal Medicine and Director of the III. Department of Medicine, University Medical Center Hamburg-Eppendorf (UKE), Florian Jehle, renal pharmaceutical industry expert and Kevin Carroll, PhD, CEO, KJC Statistics.
“Our KOL event has shed light on the profound existing medical need of halting disease progression in kidney disease. It clearly outlined that, despite a number of treatments available and scientific advances made in this field over the past years, novel medicines are needed with mechanisms of action suitable to addressing the key inflammatory and fibrotic pathways underlying this disease,” said Frank Weber, MD, CEO of Vivoryon. “I would like to thank all speakers for participating and sharing their knowledge and unique perspectives shaped by their core expertise in key aspects of drug development in kidney disease. Building on the strong body of evidence of varoglutamstat's ability to protect and improve kidney function, observed in particular in patients with diabetes, we now look forward to keeping the market updated on our progress in fully realizing the potential of Vivoryon's lead asset varoglutamstat in kidney disease.”
Highlights from Dr. Huber's presentation include:
Highlights from Mr. Jehle's presentation include:
Highlights from Dr. Carroll's presentation include:
A replay of the webcast of the virtual R&D Event will be available via the Presentations & Webcasts page in the Investor Relations section on the Company's website at www.vivoryon.com .
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Varoglutamstat (PQ912) is a proprietary, potent and selective inhibitor of human glutaminyl cyclases QPCT and QPCTL with therapeutic potential in indications including inflammatory and fibrotic diseases, neurodegenerative diseases, cancer and others. Initially advancing development aiming to treat Alzheimer's disease (AD), varoglutamstat has been investigated in a number of different clinical studies, all of which have consistently demonstrated a favorable safety and tolerability profile both in healthy volunteers and patients with AD. Based on the known anti-inflammatory activity of varoglutamstat, the protocol for the Phase 2 VIVIAD study in AD, which was completed in the first half of 2024, included the investigation of kidney function and measurement of biomarkers of kidney inflammation and fibrosis to explore the role of QPCT/L inhibition on kidney function. Although patients in VIVIAD were selected for their AD status and not for their kidney function level, many of them had reduced kidney function due to age and/or comorbidities. Analysis showed a statistically significant benefit of varoglutamstat on a prospectively defined key kidney function endpoint (eGFR) and a significant reduction of the pro-inflammatory cytokine pE-CCL2. A substantially higher treatment benefit of varoglutamstat on eGFR was observed in a post-hoc diabetes subgroup, triggering plans to advance varoglutamstat into Phase 2 study in DKD, which is currently in planning.
Vivoryon is a clinical stage biotechnology company focused on developing innovative small molecule-based medicines. Driven by its passion for ground-breaking science and innovation, the Company strives to change the lives of patients in need suffering from severe diseases. The Company leverages its in-depth expertise in understanding post-translational modifications to develop medicines that modulate the activity and stability of proteins which are altered in disease settings. The Company has established a pipeline of orally available small molecule inhibitors for various indications including Alzheimer's disease, inflammatory and fibrotic disorders, including of the kidney, and cancer.
www.vivoryon.com .
Investor Contact
Dr. Manuela Bader, Director IR & Communication
Email:
IR@vivoryon.com
Media Contact
Stephanie May
Tel: +49 171 1855682
Email: vivoryon@trophic.eu
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