IBC Addresses Critical Supply Shortages of Ac-225 with Commercially Available Molecular Recognition Technology™ (MRT™) for Highly Selective Separation of Ac-225

In parallel, increased regulatory scrutiny of the impurity profile of Ac-225, in particular the presence of impurities such as the long-lived radionuclide Ac-227, demands a step-change in the quality, purity and durability of Ac-225 production.

IBC's innovative flowsheets have been designed specifically to equip producers of Ac-225 to streamline and improve their production processes and enhance the recycling recovery rates of valuable target material, especially Ra-226, thereby alleviating critical shortages for a key therapeutic radionuclide.

Flowsheets for the individual separation of Ac-225 and Ra-226 are based on highly selective MRT™ resins and processes, commercially launched by IBC in 2023. 

IBC Launches Full Range of Best-in-Class Molecular Recognition Technology™ (MRT™) Flowsheets for Highly Selective Separations of Key Radionuclides and Preparation of Novel Chelating Agents for Radionuclide Incorporation into Radiopharmaceuticals (prnewswire.com)

Manufactured exclusively by IBC in the United States, MRT™ resins consist of predesigned, highly metal-selective ligands covalently attached to solid supports, such as silica gel or polymer substrates. MRT™ resins can be reused repeatedly and individually bind Ac-225 and Ra-226 with exceptionally high selectivity in packed column mode. The bound target Ac-225 or Ra-226 is removed via elution with very high rates of purity and recovery, up to 99.99% pure and 99.9+% yield, using chemically simple solutions. Excellent radiolytic stability and reusability of MRT™ resins ensure a sustainable process with minimal waste generation.

Dr. Robert G. G. Holmes, former Chief Scientist at Canadian Nuclear Labs, commented, "IBC offer proven flowsheets for highly selective separation of Ac-225 and Ra-226. The use of MRT™ resins to obtain exceptionally high yields and purities promise to alleviate the current critical supply shortage by making more Ac-225 available."

Steven R. Izatt, President and CEO of IBC, commented, "IBC's proprietary MRT™ resins have been shown to achieve exceptionally high recovery yields and purities, as well as radiolytic stability for multiple cycle reusability. MRT™ flow sheets substantially reduce production time, dramatically increase output and generate minimal waste, thereby resulting in a sustainable process for long-term supply of Ac-225. "

Background of IBC

IBC is an award-winning manufacturer and supplier of highly selective separations products, engineered systems and processes using Molecular Recognition Technology™ (MRT™). Based on green chemistry and green engineering principles, IBC's MRT™ products and associated processes are used worldwide in medical, mining, metals, manufacturing, environmental, analytical and laboratory applications.

https://ibcmrt.com/ 

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