Transgene to Present a Poster on Updated Data for TG4050 at SITC 2024

Transgene will present median 24-month follow up data from patients enrolled in the Phase I trial evaluating the individualized cancer vaccine TG4050 in the adjuvant treatment of head and neck cancerStrasbourg, France, October 7, 2024, 8 a.m. CET –Transgene (Euronext Paris: TNG),a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, will presenta poster highlighting median 24-month follow up from the ongoing randomized Phase I trial of...

Illkirch Graffenstaden, 07/10/2024 (informazione.it - comunicati stampa - economia)

Transgene will present median 24-month follow up data from patients
enrolled in the Phase I trial evaluating the individualized cancer vaccine TG4050
in the adjuvant treatment of head and neck cancer

Strasbourg, France, October 7, 2024, 8 a.m. CET – a biotech company that designs and develops virus-based immunotherapies for the treatment of cancer, will present This presentation will emphasize efficacy and disease-free survival outcomes in patients with head and neck cancers. SITC annual meeting will take place in Houston, Texas, USA, from November 6 to 10, 2024.

The abstract will be available on the SITC website on November 5, 2024, from 3 p.m. CET.

Poster details

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TG4050 is an individualized immunotherapy being developed for solid tumors that is based on Transgene's ® technology and powered by NEC's longstanding artificial intelligence (AI) expertise. TG4050 is being evaluated in a randomized multicenter Phase I/II clinical trial as a single agent in the adjuvant treatment of HPV-negative head and neck cancers ( NCT04183166 ).

Transgene previously presented data in April 2024, that showed that all patients who received TG4050 remained disease-free after a median follow-up of 18.6 months, comparing favorably to the observational arm which saw 3 out of 16 patients relapse during the same time period.

Transgene and NEC are continuing the joint development of TG4050 in this indication with a Phase II extension of the trial, which is currently enrolling patients.

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Transgene (Euronext: TNG) is a biotechnology company focused on designing and developing targeted immunotherapies for the treatment of cancer. Transgene's programs utilize viral vector technology with the goal of indirectly or directly killing cancer cells.
The Company's clinical-stage programs consist of a portfolio of therapeutic vaccines and oncolytic viruses:
TG4050, the first individualized therapeutic vaccine based on the ® platform, TG4001 for the treatment of HPV-positive cancers, as well as BT-001 and TG6050, two oncolytic viruses based on the Invir.IO® viral backbone.
With Transgene's ® platform, therapeutic vaccination enters the field of precision medicine with a novel immunotherapy that is fully tailored to each individual. The ® approach allows the generation of a virus-based immunotherapy that encodes patient-specific mutations identified and selected by Artificial Intelligence capabilities provided by its partner NEC.
With its proprietary platform Invir.IO®, Transgene is building on its viral vector engineering expertise to design a new generation of multifunctional oncolytic viruses.
Additional information about Transgene is available at: www.transgene.fr
Follow us on social media: X (previously-Twitter): @TransgeneSA – LinkedIn: @Transgene

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