B.More Collaborator, Dr. Michael Bogenschutz, Awarded NIAAA Grant for Psilocybin in Alcohol Use Disorder Trial at NYU and Silver Hill Hospital

According to Carey Turnbull, Co-founder, and CEO of B.More Inc., "The awarding of this NIAAA grant is a significant recognition of Dr. Bogenschutz's pioneering work in developing new treatment modalities for alcohol use disorder. Building on the groundbreaking results of his well-publicized Phase 2a study on psilocybin for AUD, this trial has the potential to pave the way for more effective treatments for AUD and other substance use disorders, providing new hope for millions struggling with addiction. We are pleased to partner with Dr. Bogenschutz and his team to support this important work."

The double-blind, randomized, placebo-controlled Phase 2 trial aims to explore the therapeutic neural mechanisms of psilocybin in AUD patients using advanced functional magnetic resonance imaging (fMRI). The study will investigate treatment differences between high-dose (30 mg) and inactive placebo, focusing on changes in fMRI metrics, drinking outcomes, and self-reported measures of negative emotionality, craving, and executive function. Additionally, the trial will seek to identify neural predictors of successful treatment outcomes, particularly in response to high-dose psilocybin.

In collaboration with SHH, the trial will randomize 120 participants from SHH's 28-day residential treatment program. Primary outcomes will measure changes in neural activation, connectivity, and self-reported alcohol use and related psychological measures. SSH, in New Canaan, Connecticut, is a nationally recognized, not-for-profit hospital for the treatment of psychiatric and addictive disorders, treating over 3,500 patients annually.

'We are pleased to be a part of this crucial trial advancing the care of individuals with alcohol use disorder," said Andrew J. Gerber, MD, PhD, President and Medical Director of Silver Hill and site director for this study.

"We are excited to embark on this significant study, which has the potential to help advance the treatment of alcohol use disorder," said Dr. Michael Bogenschutz. "The generous support from the NIAAA underscores the promise of psilocybin as a transformative therapy for substance abuse disorders. We are committed to advancing our understanding of how psilocybin impacts neural mechanisms and contributes to recovery."

About B.More

Founded in 2017 by Carey and Claudia Turnbull, B.More is a 501(c)(3) non-profit, clinical-stage biopharmaceutical company with a mission to develop better treatment options for those struggling with alcohol use disorder and other substance use disorders.  Named after Claudia Turnbull's brother, Brett Moore, who died of a drug overdose 50 years ago, B.More is focused on the development and commercialization of psychedelic medicines that offer the potential to dramatically improve the lives of those for whom current treatment options have not proved effective.  With researchers at the NYU Grossman School of Medicine, B.More is advancing clinical research to help these individuals, and their loved ones, live a better tomorrow.

For more information, please visit www.bmoreinc.org

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