deCODE genetics/Amgen: New Study Explores the Role of BMI in Disease Risk

The results showed that for some conditions, such as fatty liver disease, glucose intolerance, and knee replacement, the genetic link to disease disappeared when BMI was taken into account. For other conditions, like type 2 diabetes, heart failure, and stroke, the effects were largely reduced but not entirely explained by BMI.

The study found similar patterns in men and women, although there were some differences, especially for myocardial infarction (heart attack), suggesting that sex may play a role in how BMI influences disease risk. The scientists also noted that other factors, such as changes in BMI over time rather than BMI measured at one point in time or other factors strongly correlated with BMI, might explain some of the remaining risk.

This research highlights the importance of BMI in the pathogenesis of diseases that are more common in obese people than  others suggesting that just reducing BMI could lower the risk of these diseases.

Link to video: https://vimeo.com/1023255678/5728d8badb

Video - https://mma.prnewswire.com/media/2554046/Kari_Gudmundur_Video.mp4

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